Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P2RX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | P2RX2 |
| Chromosome | 12q24.31 |
| Protein Type | Gene |
| Function | The P2RX2 gene encodes the P2X2 subunit, one of seven subunits (P2X1-7) that form ATP-gated non-selective cation channels |
| Primary Expression | various brain regions and contributes to synaptic transmission, auditory function, and autonomic regulation |
| UniProt ID | Q9UBL9 |
| NCBI Gene ID | 22998 |
| Ensembl ID | ENSG00000171867 |
| GeneCards | P2RX2 |
| Human Protein Atlas | P2RX2 |
| Slow desensitization | P2X2 receptors desensitize slowly compared to other P2X subunits, allowing prolonged ATP responses |
| Dual gating | Can be activated by low concentrations of ATP and also by acidic pH |
| Wide tissue distribution | Expressed in neurons, glial cells, and various peripheral tissues |
| Topology | Two transmembrane domains (TM1 and TM2), with extracellular loop containing ATP binding site |
| Subunit composition | Forms trimers (either homomeric P2X2 or heteromeric P2X2/3, P2X2/5, P2X2/6) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
P2RX2["P2RX2"]
neurodegeneration["neurodegeneration"]
P2RX2 -->|"implicated_in"| neurodegeneration
style P2RX2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning P2RX2 in their description or question text
No additional research found