Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PACRG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PACRG |
| Full Name | Parkin Co-regulated Protein |
| Chromosome | 6q26 |
| Function | is a cytosolic protein that plays a critical role in mitochondrial quality control through its co-regulation with the E3 ubiquitin ligase Parkin (encoded by PARK2). |
| Primary Expression | Ubiquitous, high in brain |
| Molecular Weight | 37 kDa |
| Amino Acids | 299 aa |
| UniProt ID | Q9H0M0 |
| NCBI Gene ID | 10652 |
| OMIM | 607571 |
| GeneCards | PACRG |
| Human Protein Atlas | PACRG |
| Genomic location | 6q26 (human) |
| Alternative splicing | Multiple transcript variants encode isoforms with varying N-terminal regions |
| Conservation | Highly conserved across vertebrates |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PACRG["PACRG"]
neurodegeneration["neurodegeneration"]
PACRG -->|"implicated_in"| neurodegeneration
style PACRG fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PACRG in their description or question text
No additional research found