Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PADI4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| h-3b539acf | targeted_by | hypothesis | 1.00 |
| NET_formation | catalyzes | process | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-3b539acf | targets | hypothesis | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Neutrophil Extracellular Trap (NET) Inhibition | 0.806 | - | Blood-brain barrier tight junction disru |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.806
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Neutrophil extracellular traps in central nervous system disorders: mechanisms, [PMID:40469282] | Qiao S, Yuan J, Zhang SC | Front Immunol | 2025 | 0 |
| NETosis in Alzheimer's Disease: Understanding the Role of Neutrophil Extracellul [PMID:41460435] | Rao R, Verma H, Gangwar P | Mol Neurobiol | 2025 | 0 |
| Integrating network pharmacology and transcriptomic omics reveals that akebia sa [PMID:38149910] | Gu L, Ye L, Chen Y | FASEB J | 2024 | 0 |
| Blood-brain crosstalk: the roles of neutrophils, platelets, and neutrophil extra [PMID:37500363] | Chou Ming-Li; Babamale Abdulkareem Olare | Trends in neurosciences | 2023 | 0 |
| Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neuro [PMID:37550658] | Kunze R, Fischer S, Marti HH | J Biomed Sci | 2023 | 0 |
| NETosis in Alzheimer's Disease. [PMID:28303140] | Pietronigro EC, Della Bianca V, Zenaro E | Front Immunol | 2017 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
closed · Rounds: 7 · Score: 0.87 · 2026-04-16
Hypotheses and analyses mentioning PADI4 in their description or question text
No additional research found