Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PAHX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PAHX |
| Full Name | Peroxisomal 2-Hydroxyacyl-CoA Lyase |
| Chromosome | 10p13 |
| Protein Type | Enzyme |
| Function | ### Enzyme Activity and Substrate Specificity |
| Primary Expression | tissues with active peroxisomal metabolism: |
| UniProt ID | Q9NXK5 |
| NCBI Gene ID | 55627 |
| Ensembl ID | ENSG00000107882 |
| GeneCards | PAHX |
| Human Protein Atlas | PAHX |
| Substrate specificity | Prefers 2-hydroxy branched-chain fatty acyl-CoA substrates |
| Co-factor requirements | Requires CoA as a cofactor and produces acetyl-CoA as a product |
| Cellular localization | Exclusively peroxisomal matrix enzyme |
| Pathway position | Acts downstream of acyl-CoA oxidase in the beta-oxidation chain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PAHX["PAHX"]
neurodegeneration["neurodegeneration"]
PAHX -->|"implicated_in"| neurodegeneration
style PAHX fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PAHX in their description or question text
No additional research found