Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PAK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
p21-Activated Kinase 2: A serine/threonine kinase involved in cytoskeletal dynamics, synaptic plasticity, tau phosphorylation, and apoptosis in neurodegenerative diseases
No AI portrait yet
| Gene Symbol | PAK2 |
| Function | The p21-activated kinases (PAKs) represent a family of serine/threonine kinases that function as downstream effectors of small GTPases, particularly RAC1 and CDC42[@bokoch2003]. |
| Molecular Weight | 58 kDa |
| Amino Acids | 524 aa |
| GeneCards | PAK2 |
| Human Protein Atlas | PAK2 |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Gene expression"] --> B["PAK2"]
B --> C["Protein folding and
quality control"]
B --> D["Cellular signaling"]
C --> E["Proteostasis"]
D --> F["Neurotoxicity"]
E --> G["Disease outcome"]
F --> G
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class B protein
class G disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PAK2 in their description or question text
No additional research found