gene

PARD6B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARD6B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PARD6B (Partitioning Defect 6 Beta) is a key polarity protein in the PAR3/PAR6/aPKC complex, essential for neuronal development, synaptic formation, and cell polarity. Implicated in neurodegenerative disease pathogenesis through effects on neuronal connectivity.

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🧬 Gene Info

Gene Symbol	PARD6B
Full Name	Partitioning Defect 6 Beta
Chromosome	20q13.33
Function	is a critical component of the PAR (Partitioning Defect) polarity complex that controls cell polarity establishment and maintenance in epithelial cells, neurons, and other cell types.
Primary Expression	brain and other tissues, with particularly high expression during development
Amino Acids	372 aa
Exons	10
UniProt ID	Q9UPV9
NCBI Gene ID	25852
Ensembl ID	ENSG00000177383
OMIM	608155
GeneCards	PARD6B
Human Protein Atlas	PARD6B
Alternative Names	PAR-6B, Par6B
Protein Class	Polarity protein; Scaffold protein
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PARD6B["<b>PARD6B</b>"]
    neurodegeneration["neurodegeneration"]
    PARD6B -->|"implicated in"| neurodegeneration
    Neurodegenerative_Disease{"Neurodegenerative Disease"}
    PARD6B -->|"implicated in"| Neurodegenerative_Disease
    Neuronal_Development(["Neuronal Development"])
    PARD6B -->|"regulates"| Neuronal_Development
    style PARD6B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Neurodegenerative_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neuronal_Development fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found