gene

PARD6B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARD6B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PARD6B (Partitioning Defect 6 Beta) is a key polarity protein in the PAR3/PAR6/aPKC complex, essential for neuronal development, synaptic formation, and cell polarity. Implicated in neurodegenerative disease pathogenesis through effects on neuronal connectivity.

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🧬 Gene Info

Gene Symbol	PARD6B
Full Name	Partitioning Defect 6 Beta
Chromosome	20q13.33
Function	is a critical component of the PAR (Partitioning Defect) polarity complex that controls cell polarity establishment and maintenance in epithelial cells, neurons, and other cell types.
Primary Expression	brain and other tissues, with particularly high expression during development
Amino Acids	372 aa
Exons	10
UniProt ID	[Q9UPV9](https://www.uniprot.org/uniprot/Q9UPV9)
Ensembl ID	ENSG00000177383
OMIM	608155
GeneCards	PARD6B
Human Protein Atlas	PARD6B
C. elegans	par-6 is essential for cell polarity and asymmetric cell division
Drosophila	Par6 regulates epithelial polarity and neurogenesis
Mammals	Three isoforms (PARD6A, B, G) with tissue-specific expression
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PARD6B Gene

gene · 2432 words

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Pathway Diagram

graph TD
    PARD6B["PARD6B"]
    neurodegeneration["neurodegeneration"]
    PARD6B -->|"implicated in"| neurodegeneration
    Neurodegenerative_Disease{"Neurodegenerative Disease"}
    PARD6B -->|"implicated in"| Neurodegenerative_Disease
    Neuronal_Development(["Neuronal Development"])
    PARD6B -->|"regulates"| Neuronal_Development
    style PARD6B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Neurodegenerative_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Neuronal_Development fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARD6B in their description or question text

No additional research found