Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PATHWAYS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| AMELOBLASTOMA | associated_with | disease | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 40858976 | highlighted as shared inflammatory | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial Disease-Associated States: TREM2-Independent Path | 0.710 | neurodegeneration | Cell type vulnerability debate in Alzhei |
| SYK-Independent TREM2 Pathways Remain Functional in TYROBP D | 0.548 | neuroinflammation | Why is TYROBP deficiency neuroprotective |
| Dendritic tau missorting persists through local proteostatic | 0.530 | neurodegeneration | Does tau dendritic missorting persist in |
| Astrocytic TREM2-Like Receptor Modulation of Synaptic Streng | 0.380 | connectomics | Human connectome alterations in Alzheime |
| SULF-Mediated Protection of Cholinergic Tau Transport Pathwa | 0.380 | neuroscience | Trans-synaptic tau spreading and propaga |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Molecular sabotage of hippocampal synaptic plasticity by amyloid-β in Alzheimer' [PMID:41929946] | ["Behroozi Zahra", "Askarpour Hedyeh", " | Journal of Alzheimer's disease | 2026 | 0 |
| Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in e [PMID:32991925] | Unknown | Behav Brain Res | 2021 | 0 |
| Disease-modifying treatment with I(2) imidazoline receptor ligand LSL60101 in an [PMID:33817786] | Unknown | Br J Pharmacol | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PATHWAYS in their description or question text
No additional research found