gene

PCYT1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCYT1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PCYT1B encodes CCT-beta, the rate-limiting enzyme in phosphatidylcholine biosynthesis, critical for membrane biogenesis, myelin maintenance, and synaptic function in neurons

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🧬 Gene Info

Gene Symbol	PCYT1B
Full Name	Phosphate Cytidylyltransferase 1, Choline, Beta
Chromosome	Xq13.1
Protein Type	Enzyme
Function	is a key regulatory enzyme in the CDP-choline pathway for phosphatidylcholine (PC) biosynthesis.
Primary Expression	the brain, particularly in neurons and oligodendrocytes
Molecular Weight	42 kDa
Amino Acids	367 aa
Gene Type	Protein coding
UniProt ID	Q9Y5K6
NCBI Gene ID	9468
Ensembl ID	ENSG00000102265
OMIM	300169
GeneCards	PCYT1B
Human Protein Atlas	PCYT1B
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PCYT1B — AlphaFold Q9Y5K6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PCYT1B Gene

gene · 2602 words

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Pathway Diagram

graph TD
    PCYT1B["PCYT1B"]
    neurodegeneration["neurodegeneration"]
    PCYT1B -->|"implicated_in"| neurodegeneration
    style PCYT1B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PCYT1B in their description or question text

No additional research found