Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PDE1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PDE1B is a calcium/calmodulin-dependent phosphodiesterase highly expressed in brain, regulating cAMP/cGMP signaling in neurons. Implicated in Parkinson's disease, cognitive disorders, and neurodegenerative processes.
| Gene Symbol | PDE1B |
| Full Name | Phosphodiesterase 1B |
| Chromosome | 21q22.11 |
| Function | is a 536-amino acid protein with a characteristic phosphodiesterase domain structure |
| Primary Expression | Brain (striatum, hippocampus, cortex) |
| Amino Acids | 536 aa |
| UniProt ID | [Q01065](https://www.uniprot.org/uniprot/Q01065) |
| Ensembl ID | ENSG00000184518 |
| OMIM | 607323 |
| GeneCards | PDE1B |
| Human Protein Atlas | PDE1B |
| Basal state | In the absence of elevated calcium, PDE1B has minimal activity |
| Calcium influx | When neuronal activity increases intracellular calcium, calcium-bound calmodulin activates PDE1B |
| Signal termination | Activated PDE1B rapidly hydrolyzes cAMP/cGMP, effectively terminating the signal |
| Reset | When calcium returns to baseline, calmodulin dissociates and PDE1B returns to the inactive state |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PDE1B["PDE1B"]
neurodegeneration["neurodegeneration"]
PDE1B -->|"implicated_in"| neurodegeneration
style PDE1B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||