gene

PDE5A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PDE5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Phosphodiesterase 5A in cGMP signaling and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	Phosphodiesterase 5A
Chromosome	4q27
Protein Type	Enzyme
Function	encodes a cyclic nucleotide phosphodiesterase that specifically hydrolyzes cyclic guanosine monophosphate (cGMP).
Exons	26
UniProt ID	O76074
NCBI Gene ID	8654
Ensembl ID	ENSG00000138735
OMIM	603571
PDE5A1	Full-length canonical isoform
PDE5A2	Alternative N-terminus isoform
PDE5A3	Testis-specific isoform
Synaptic plasticity	cGMP-dependent LTP and LTD
Memory formation	Hippocampal learning and consolidation
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PDE5A — AlphaFold O76074 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDE5A Gene

gene · 965 words

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Pathway Diagram

graph TD
    PDE5A["PDE5A"]
    neurodegeneration["neurodegeneration"]
    PDE5A -->|"implicated_in"| neurodegeneration
    style PDE5A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PDE5A in their description or question text

No additional research found