gene

PDE6B

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PDE6B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PDE6B is the beta subunit of rod photoreceptor phosphodiesterase, critical for phototransduction and implicated in retinal degeneration and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	PDE6B
Full Name	Phosphodiesterase 6B
Chromosome	4p16.3
Function	encodes a protein of 847 amino acids.
Amino Acids	847 aa
Pathways	cascade: ### Dark State
UniProt ID	P16404
NCBI Gene ID	5159
Ensembl ID	ENSG00000133250
GeneCards	PDE6B
Human Protein Atlas	PDE6B
N-terminal region	Mediates interaction with PDE6A and regulation by PDE6G inhibitory subunits
Catalytic domain	Contains the phosphodiesterase active site that hydrolyzes cGMP
C-terminal region	Important for holoenzyme assembly and membrane localization
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PDE6B — AlphaFold P16404 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDE6B — Phosphodiesterase 6B

gene · 1220 words

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Pathway Diagram

graph TD
    PDE6B["PDE6B"]
    neurodegeneration["neurodegeneration"]
    PDE6B -->|"implicated_in"| neurodegeneration
    style PDE6B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PDE6B in their description or question text

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