PDIA6

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolPDIA6
Nameprotein disulfide isomerase family A member 6
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple

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