gene

PDS5A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PDS5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PDS5A - PDS5 Cohesin Associated Factor A

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🧬 Gene Info

Gene Symbol	PDS5A
Full Name	PDS5 Cohesin Associated Factor A
Aliases	Page for PDS5A
Function	non-cohesive cohesin states[@shintomi2009]
UniProt ID	Q29RF7
Ensembl ID	ENSG00000121570
GeneCards	PDS5A
Human Protein Atlas	PDS5A
Recruits WAPL	Mediates the prophase pathway of cohesin removal
Interacts with SORORIN	Balances cohesive vs. non-cohesive cohesin states[@shintomi2009]
Cohesion establishment	Working with ESCO1/ESCO2 acetyltransferases
Cohesion maintenance	Protecting established cohesion during G2
Controlled release	Enabling proper chromosome segregation at anaphase[@dorsett2012]
CTCF binding	Modulating cohesin-CTCF interactions at TAD boundaries
Enhancer-promoter contacts	Regulating long-range chromatin looping
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PDS5A — AlphaFold Q29RF7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PDS5A - PDS5 Cohesin Associated Factor A

gene · 650 words

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Pathway Diagram

graph TD
    PDS5A["PDS5A"]
    neurodegeneration["neurodegeneration"]
    PDS5A -->|"implicated_in"| neurodegeneration
    style PDS5A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PDS5A in their description or question text

No additional research found