gene

PDYN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

PDYN (Prodynorphin) encodes the precursor protein for dynorphin opioid peptides, which are involved in pain modulation, stress responses, and dopaminergic signaling. Dysregulated PDYN expression contributes to Parkinson's disease, Alzheimer's disease, and psychiatric disorders.

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🧬 Gene Info

Gene Symbol	PDYN
Full Name	Prodynorphin
Chromosome	20p13
Protein Family	Opioid precursor proteins
Function	is a 254-amino acid precursor protein with a molecular weight of approximately 28 kDa.
Molecular Weight	28 kDa
Amino Acids	254 aa
UniProt ID	P01213
NCBI Gene ID	5175
Ensembl ID	ENSG00000101336
OMIM	131340
GeneCards	PDYN
Human Protein Atlas	PDYN
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PDYN — AlphaFold P01213 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PDYN Gene

gene · 2048 words

→

PDYN Protein

protein · 581 words

→

Pathway Diagram

graph TD
    PDYN["PDYN"]
    neurodegeneration["neurodegeneration"]
    PDYN -->|"implicated in"| neurodegeneration
    Alzheimer_S_Disease{"Alzheimer'S Disease"}
    PDYN -->|"implicated in"| Alzheimer_S_Disease
    Parkinson_S_Disease{"Parkinson'S Disease"}
    PDYN -->|"implicated in"| Parkinson_S_Disease
    DOPAMINE["DOPAMINE"]
    PDYN ---|"interacts"| DOPAMINE
    style PDYN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Alzheimer_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PDYN in their description or question text

No additional research found