gene

PEX12

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PEX12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	PEX12
Chromosome	17q12
Protein Family	RING finger protein family
Function	is a RING finger peroxisomal membrane protein that functions as an E3 ubiquitin ligase essential for peroxisome biogenesis.
Subcellular Localization	Peroxisomal membrane
Molecular Weight	40 kDa
Amino Acids	359 aa
UniProt ID	O00312
GeneCards	PEX12
Human Protein Atlas	PEX12
N-terminal region	Cytoplasmic domain for PEX5 interaction
RING finger domain	C3HC4-type zinc finger for E3 ligase activity
C-terminal region	Peroxisomal membrane anchor
PEX5-binding site	Direct interaction with peroxin
E3 ubiquitin ligase activity	Catalyzes ubiquitination of PEX5
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PEX12 — AlphaFold O00312 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PEX12 (Peroxisome Biogenesis Factor 12)

gene · 1423 words

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PEX12 Protein

protein · 629 words

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Pathway Diagram

graph TD
    PEX12["PEX12"]
    neurodegeneration["neurodegeneration"]
    PEX12 -->|"implicated_in"| neurodegeneration
    style PEX12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PEX12 in their description or question text

No additional research found