protein

PGRMC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PGRMC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PGRMC1 Protein

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🔬 Protein Info

Gene Symbol	PGRMC1
Protein Type	Receptor
Function	is a heme-binding membrane protein that serves a.
Primary Expression	neurons and glial cells throughout the brain, including the cerebral cortex, [hippocampus](/brain-region
Subcellular Localization	</th><td>Endoplasmic reticulum, plasma membrane, nucleus</td></tr>
Molecular Weight	21.6 kDa
GeneCards	PGRMC1
Human Protein Atlas	PGRMC1
Alzheimer's disease	PGRMC1 levels are altered in AD brain tissue, and it interacts with amyloid-beta processing machinery. Some evidence suggests it may protect against amyloid-beta induced toxicity[@cai2020]
Parkinson's disease	PGRMC1 expression is modified in PD models, and its neuroprotective properties may be relevant to dopaminergic neuron survival[@gatto2015]
Aging	Age-related changes in PGRMC1 expression may contribute to reduced cellular resilience in the aging brain[@liu2021]
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PGRMC1 Protein

protein · 528 words

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Pathway Diagram

graph TD
    PGRMC1["PGRMC1"]
    neurodegeneration["neurodegeneration"]
    PGRMC1 -->|"implicated_in"| neurodegeneration
    style PGRMC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PGRMC1 in their description or question text

No additional research found