gene

POLD2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POLD2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

POLD2 encodes the p50 subunit of DNA polymerase delta, essential for DNA replication, repair, and genome stability. Implicated in neurodegeneration, cancer, and aging.

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🧬 Gene Info

Gene Symbol	POLD2
Full Name	DNA Polymerase Delta Subunit 2
Chromosome	7q11.23
Primary Expression	Ubiquitous, high in proliferating cells
Molecular Weight	50 kDa
Amino Acids	466 aa
Exons	10
Ensembl ID	ENSG00000106628
OMIM	600151
GeneCards	POLD2
Human Protein Atlas	POLD2
Lagging strand DNA synthesis	Primary enzyme for Okazaki fragment synthesis
DNA repair pathways	Essential for base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MM)
Genome stability maintenance	Prevents replication stress and DNA damage accumulation
Cellular proliferation	Critical for S-phase progression and cell division
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

POLD2 — DNA Polymerase Delta Subunit 2

gene · 1645 words

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POLD2 Protein

protein · 558 words

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Pathway Diagram

graph TD
    POLD2["POLD2"]
    neurodegeneration["neurodegeneration"]
    POLD2 -->|"implicated_in"| neurodegeneration
    style POLD2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning POLD2 in their description or question text

No additional research found