Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POLN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | POLN |
| Full Name | DNA Polymerase Nu |
| Chromosome | 4p16.3 |
| Protein Family | DNA polymerase X-family |
| Protein Type | Enzyme |
| Function | is a specialized DNA polymerase primarily implicated in DNA repair pathways, particularly those involved in maintaining genomic stability in neurons. |
| Primary Expression | Ubiquitous, highest in testis and brain |
| Molecular Weight | 42 kDa |
| Amino Acids | 369 aa |
| UniProt ID | Q8IY92 |
| NCBI Gene ID | 128312 |
| Ensembl ID | ENSG00000131368 |
| OMIM | 611410 |
| GeneCards | POLN |
| Human Protein Atlas | POLN |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
POLN["POLN"]
neurodegeneration["neurodegeneration"]
POLN -->|"implicated_in"| neurodegeneration
style POLN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning POLN in their description or question text
No additional research found