gene

PON3

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PON3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	PON3
Full Name	Paraoxonase 3
Chromosome	7q21.3
Function	encodes a member of the paraoxonase gene family, which also includes PON1 and PON2.
Molecular Weight	39 kDa
Amino Acids	354 aa
UniProt ID	Q15166
NCBI Gene ID	5446
Ensembl ID	ENSG00000005421
OMIM	605450
GeneCards	PON3
Human Protein Atlas	PON3
N-terminal signal peptide	26 amino acids directing secretion
Six-bladed β-propeller	Central structural motif characteristic of the paraoxonase family
Active site	Conserved serine hydrolase active site with catalytic triad
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PON3 — AlphaFold Q15166 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PON3 — Paraoxonase 3

gene · 1659 words

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Paraoxonase 3 (PON3) Protein

protein · 799 words

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Pathway Diagram

graph TD
    PON3["PON3"]
    neurodegeneration["neurodegeneration"]
    PON3 -->|"implicated_in"| neurodegeneration
    style PON3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PON3 in their description or question text

No additional research found