gene

POU3F3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POU3F3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

Comprehensive overview of POU3F3 (Brn-1), a POU domain transcription factor critical for cortical development, neuronal differentiation, and cognitive function, with implications for Alzheimer's disease and neurodevelopmental disorders.

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🧬 Gene Info

Gene Symbol	POU3F3
Full Name	POU Class 3 Homeobox 3 (Brn-1)
Aliases	Brn-1
Chromosome	19q13.43
Protein Type	Transcription Factor
Function	is a member of the POU (Pit-Oct-Unc) domain family of transcription factors.
Primary Expression	the developing nervous system and maintained in specific neuronal populations in the adult brain, where it continues to regulate gene expression progr
Amino Acids	449 aa
Exons	2
UniProt ID	Q9YCI4
NCBI Gene ID	5455
Ensembl ID	ENSG00000198914
OMIM	604407
GeneCards	POU3F3
Human Protein Atlas	POU3F3
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: POU3F3 — AlphaFold Q9YCI4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

POU3F3 — POU Class 3 Homeobox 3 (Brn-1)

gene · 1473 words

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Pathway Diagram

graph TD
    POU3F3["POU3F3"]
    neurodegeneration["neurodegeneration"]
    POU3F3 -->|"implicated_in"| neurodegeneration
    style POU3F3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning POU3F3 in their description or question text

No additional research found