Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPP1R2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information on PPP1R2 (Inhibitor-2), a regulatory subunit of protein phosphatase 1 involved in neurodegenerative diseases
No AI portrait yet
| Gene Symbol | PPP1R2 |
| Full Name | Protein Phosphatase 1 Regulatory Subunit 2 (Inhibitor-2) |
| Aliases | Inhibitor-2 |
| Chromosome | 3p21.3 |
| Function | is a heat-stable regulatory protein that potently inhibits the catalytic activity of protein phosphatase 1 (PP1). |
| Primary Expression | virtually all human tissues, with highest expression in brain, liver, skeletal muscle, and heart |
| Molecular Weight | 23 kDa |
| Amino Acids | 206 aa |
| UniProt ID | P53611 |
| NCBI Gene ID | 5500 |
| Ensembl ID | ENSG00000165416 |
| GeneCards | PPP1R2 |
| Human Protein Atlas | PPP1R2 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
A["Upstream Regulators"] --> B["PPP1R2"]
B --> C["Molecular Mechanism"]
C --> D["Cellular Effects"]
D --> E["Pathological Consequences"]| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PPP1R2 in their description or question text
No additional research found