Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPP1R9B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PPP1R9B encodes spinophilin, a neuronal-specific phosphatase regulatory subunit critical for synaptic plasticity, dendritic spine morphology, and receptor signaling in neurodegenerative diseases.
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| Gene Symbol | PPP1R9B |
| Full Name | Spinophilin |
| Chromosome | 17q21.33 |
| Function | regulatory subunit critical for synaptic plasticity |
| UniProt ID | [Q9Y2J8](https://www.uniprot.org/uniprot/Q9Y2J8) |
| Ensembl ID | ENSG00000127314 |
| GeneCards | PPP1R9B |
| Human Protein Atlas | PPP1R9B |
| Directs PPP1 to dendritic spines | the RVxF motif in spinophilin binds the PPP1 catalytic subunit |
| Recruits PPP1 to postsynaptic densities | targets both NMDA and AMPA receptor complexes |
| Substrate specificity | modulates PPP1 activity toward specific substrates including: |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PPP1R9B["PPP1R9B"]
neurodegeneration["neurodegeneration"]
PPP1R9B -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PPP1R9B in their description or question text
No additional research found