gene

PPP2R1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP2R1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PPP2R1A Gene

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🧬 Gene Info

Gene Symbol	PPP2R1A
Full Name	Protein Phosphatase 2 Regulatory Subunit A Alpha
Chromosome	19q13.41
Function	PPP2R1A encodes the alpha isoform of the PP2A subunit A, which serves as a scaffold for assembling the PP2A holoenzyme.
Pathways	PI3K, MAPK, Wnt
UniProt ID	P46821
NCBI Gene ID	5518
Ensembl ID	ENSG00000101162
OMIM	616981
GeneCards	PPP2R1A
Human Protein Atlas	PPP2R1A
Tau dephosphorylation	PP2A dephosphorylates tau at multiple pathological sites (Ser202, Thr205, Ser396, Ser404)
Signal transduction	Regulates various signaling pathways including PI3K/Akt, MAPK, and Wnt
Cell cycle control	Essential for cell cycle progression
Synaptic plasticity	Regulates NMDA receptor function and LTP
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP2R1A — AlphaFold P46821 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PPP2R1A Gene

gene · 611 words

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PP2A (PPP2R1A)

gene · 595 words

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Pathway Diagram

graph TD
    PPP2R1A["PPP2R1A"]
    neurodegeneration["neurodegeneration"]
    PPP2R1A -->|"implicated_in"| neurodegeneration
    style PPP2R1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PPP2R1A in their description or question text

No additional research found