gene

PPP2R5B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP2R5B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PPP2R5B encodes a regulatory B56β subunit of protein phosphatase 2A (PP2A), critical for tau dephosphorylation and neuronal function in Alzheimer's and Parkinson's diseases.

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🧬 Gene Info

Gene Symbol	PPP2R5B
Chromosome	14q32.31
Protein Type	Gene
Function	encodes a protein of approximately 515 amino acids.
Primary Expression	the human brain with highest levels in: - Hippocampus (CA1-CA3 regions, dentate gyrus): Critical for memory circuits - Cerebral cortex (layer
Subcellular Localization	This trimeric structure allows precise temporal and spatial regulation of PP2A activity toward specific substrates inclu
Amino Acids	515 aa
Exons	14
GeneCards	PPP2R5B
Human Protein Atlas	PPP2R5B
N-terminal region	Contains the conserved B56 domain (~150 amino acids) responsible for substrate binding and PP2A targeting
Central region	Contains multiple HEAT repeats involved in protein-protein interactions
C-terminal region	Mediates interaction with the PP2A catalytic and scaffolding subunits
Catalytic subunit (PP2AC/PPP2CA)	The active phosphatase component
Scaffold subunit (PPP2R1A/PR65A)	Provides structural framework
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP2R5B

gene · 1907 words

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Pathway Diagram

graph TD
    PPP2R5B["PPP2R5B"]
    neurodegeneration["neurodegeneration"]
    PPP2R5B -->|"implicated_in"| neurodegeneration
    style PPP2R5B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning PPP2R5B in their description or question text

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