Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRION_PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | PRNP |
| Aliases | PRION_PROTEIN |
| Chromosome | 20p13 |
| Protein Family | Prion protein family |
| Function | is a GPI-anchored glycoprotein expressed predominantly in the central nervous system. |
| Primary Expression | Cell membrane ( GPI-anchored), cytoplasm, nucleus |
| Subcellular Localization | Cell membrane ( GPI-anchored), cytoplasm, nucleus |
| Molecular Weight | 33-35 kDa (253 amino acids) |
| Amino Acids | 253 aa |
| UniProt ID | P04156 |
| GeneCards | PRNP |
| Human Protein Atlas | PRNP |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["Prion Protein"]
N1["Prion Disease"]
N0 -->|"expressed in"| N1
N2["Aging"]
N0 -->|"therapeutic target"| N2
N3["Als"]
N0 -->|"therapeutic target"| N3
N4["Ferroptosis"]
N0 -->|"activates"| N4
N5["Alzheimer"]
N0 -->|"expressed in"| N5
N6["Neurodegeneration"]
N0 -->|"regulates"| N6
N7["Neuroinflammation"]
N0 -->|"regulates"| N7
N8["Parkinson"]
N0 -->|"causes"| N8
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 disease
class N4 disease
class N5 disease
class N6 disease
class N7 disease
class N8 disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning PRION_PROTEIN in their description or question text
No additional research found