gene

PRKAR2B

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PRKAR2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for PRKAR2B — Protein Kinase A Regulatory Subunit 2B

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🧬 Gene Info

Gene Symbol	PRKAR2B
Full Name	Protein Kinase cAMP-Dependent Type II Regulatory Subunit Beta
Aliases	Protein Kinase A Regulatory Subunit 2B
Chromosome	7p22.1
Protein Family	cAMP-dependent protein kinase regulatory subunit family
Function	PRKAR2B encodes the RIIβ isoform of PKA regulatory subunit:
Amino Acids	418 aa
UniProt ID	P31321
NCBI Gene ID	5576
Ensembl ID	ENSG00000101290
GeneCards	PRKAR2B
Human Protein Atlas	PRKAR2B
cAMP Signaling	Binds cAMP to activate PKA
Kinase Regulation	Controls catalytic subunit activity
Signal Transduction	Second messenger pathway
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRKAR2B — AlphaFold P31321 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRKAR2B — Protein Kinase A Regulatory Subunit 2B

gene · 911 words

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Pathway Diagram

graph TD
    PRKAR2B["PRKAR2B"]
    neurodegeneration["neurodegeneration"]
    PRKAR2B -->|"implicated_in"| neurodegeneration
    style PRKAR2B fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRKAR2B in their description or question text

No additional research found