protein

PRPF31

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRPF31: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

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Summary

PRPF31 (Prp31) is a key spliceosome component essential for U4/U6.U5 tri-snRNP assembly and catalytic spliceosome activation. This comprehensive page covers its structure, normal neuronal function, role in neurodegenerative diseases, and therapeutic potential.

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🔬 Protein Info

Gene Symbol	PRPF31
Aliases	Prp31
Chromosome	19q13.42
Function	The tri-snRNP contains
Molecular Weight	55.6 kDa
Amino Acids	499 aa
UniProt ID	O94973
NCBI Gene ID	26121
Ensembl ID	ENSG00000105618
OMIM	607395
GeneCards	PRPF31
Human Protein Atlas	PRPF31
U4 snRNA	serves as an intronic sequence placeholder
U6 snRNA	the catalytic component of the spliceosome
U5 snRNA	recognizes the 5' and 3' splice sites
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRPF31 — AlphaFold O94973 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PRPF31 Gene

gene · 2182 words

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PRPF31 Protein

protein · 2068 words

→

Pathway Diagram

graph TD
    PRPF31["PRPF31"]
    neurodegeneration["neurodegeneration"]
    PRPF31 -->|"implicated in"| neurodegeneration
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    PRPF31 -->|"implicated in"| Neurodegenerative_Diseases
    style PRPF31 fill:#1a4a3a,stroke:#81c784,stroke-width:3px,color:#fff
    style Neurodegenerative_Diseases fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRPF31 in their description or question text

No additional research found