gene

PTCH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTCH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Patched 2 - a transmembrane receptor that negatively regulates Hedgehog signaling and plays roles in neural development, stem cell biology, and disease

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🧬 Gene Info

Gene Symbol	PTCH2
Aliases	Patched 2
Chromosome	1p34.1
Protein Type	Receptor
Function	encodes a transmembrane receptor that serves as the primary negative regulator of Hedgehog (Hh) signaling.
Molecular Weight	134 kDa
Amino Acids	207 aa
Exons	23
Ensembl ID	ENSG00000117425
GeneCards	PTCH2
Human Protein Atlas	PTCH2
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PTCH2["PTCH2"]
    neurodegeneration["neurodegeneration"]
    PTCH2 -->|"implicated_in"| neurodegeneration
    style PTCH2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found