Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PTPRT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PTPRT |
| Full Name | Protein Tyrosine Phosphatase Receptor Type T |
| Chromosome | 20q12-q13.12 |
| Protein Family | Receptor-type protein tyrosine phosphatase (RPTP) family |
| Protein Type | Receptor |
| Function | is a member of the receptor protein tyrosine phosphatase (RPTP) family. |
| Primary Expression | the nervous system where it plays critical roles in regulating synaptic connectivity, neuronal migration, and axon guidance [[moll1991]](https://pubme |
| Molecular Weight | 205 kDa |
| UniProt ID | Q9Y2P9 |
| NCBI Gene ID | 5792 |
| Ensembl ID | ENSG00000196090 |
| OMIM | 602706 |
| GeneCards | PTPRT |
| Human Protein Atlas | PTPRT |
| Alias | RPTPρ, RPTP-Sigma |
| Associated Diseases | Autism Spectrum Disorder, Intellectual Disability, Colorectal Cancer |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PTPRT["PTPRT"]
neurodegeneration["neurodegeneration"]
PTPRT -->|"implicated_in"| neurodegeneration
style PTPRT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity