entity

R136S

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about R136S: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections
1Hypotheses
1Analyses
0Outgoing
1Incoming
0Experiments
1Debates

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Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (1)

SourceRelationTypeStr
TREM2co_associated_withgene0.30

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
TREM2 Activation as an Amplification Node for R136S Protecti 0.657 neurodegeneration What molecular mechanisms underlie the d

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms underlie the dose-dependent protective effects of the

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.659

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows homozygous R136S fully rescues APOE4-driven pathology while hete

closed · Rounds: 4 · Score: 0.81 · 2026-04-14