gene

RAB30

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RAB30: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RAB30 - Golgi-localized small GTPase involved in intra-Golgi trafficking, protein sorting, and neurodegenerative disease mechanisms

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🧬 Gene Info

Gene Symbol	RAB30
Full Name	Member RAS Oncogene Family
Chromosome	11q13.2
Function	encodes a Golgi-localized small GTPase that regulates intra-Golgi trafficking and maintains Golgi apparatus organization.
Molecular Weight	22 kDa
Amino Acids	201 aa
Exons	7
UniProt ID	[Q9BTX3](https://www.uniprot.org/uniprot/Q9BTX3)
Ensembl ID	ENSG00000137547
GeneCards	RAB30
Human Protein Atlas	RAB30
GDP-bound (Inactive)	Cytosolic distribution, bound to GDP Dissociation Inhibitors (GDIs)
GTP-bound (Active)	Membrane-associated, recruits effector proteins
GTP Hydrolysis	Facilitated by GTPase-activating proteins (GAPs)
GDP/GTP Exchange	Stimulated by Guanine nucleotide Exchange Factors (GEFs)
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAB30

gene · 1453 words

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Pathway Diagram

graph TD
    RAB30["RAB30"]
    neurodegeneration["neurodegeneration"]
    RAB30 -->|"implicated_in"| neurodegeneration
    style RAB30 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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