Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB33A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB33A - Member RAS Oncogene Family - A brain-enriched Rab GTPase involved in Golgi vesicle trafficking and autophagosome formation
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| Gene Symbol | RAB33A |
| Full Name | RAB33A, Member RAS Oncogene Family |
| Chromosome | Xq26.1 |
| Function | is a brain-enriched small GTPase belonging to the RAB GTPase family. |
| Primary Expression | the central nervous system, with high expression in cerebellar Purkinje cells and cortical neurons, making it particularly relevant to neurodegenerati |
| Molecular Weight | 26 kDa |
| Amino Acids | 235 aa |
| UniProt ID | Q9H0Y5 |
| NCBI Gene ID | 10537 |
| Ensembl ID | ENSG00000145736 |
| OMIM | 300523 |
| GeneCards | RAB33A |
| Human Protein Atlas | RAB33A |
| G1 motif (P-loop) | Coordinates nucleotide binding |
| G2 motif | Provides switch function (GTP-dependent conformational change) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB33A["RAB33A"]
neurodegeneration["neurodegeneration"]
RAB33A -->|"implicated_in"| neurodegeneration
style RAB33A fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAB33A in their description or question text
No additional research found