gene

RACGAP1

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This page aggregates everything SciDEX knows about RACGAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for RACGAP1 — Rac GTPase Activating Protein 1

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🧬 Gene Info

Gene Symbol	RACGAP1
Full Name	Rac GTPase Activating Protein 1
Chromosome	12q13.12
Protein Type	GTPase activating protein (GAP)
Function	is a critical GTPase activating protein that regulates the Rho family GTPases Rac1, Cdc42, and RhoA.
Molecular Weight	71 kDa
UniProt ID	P47738
NCBI Gene ID	10505
Ensembl ID	ENSG00000113889
GeneCards	RACGAP1
Human Protein Atlas	RACGAP1
GAP domain	Catalyzes GTP hydrolysis on Rho family GTPases (Rac1, Cdc42, RhoA), converting active GTP-bound form to inactive GDP-bound form
CRIB domain	Cdc42/Rac interactive binding domain for interaction with Cdc42 and Rac1
Phosphorylation sites	Multiple serine/threonine phosphorylation sites regulate its activity and localization
Mitosis and cell division	Critical for central spindle assembly, cytokinesis, and accurate chromosome segregation. RACGAP1 localizes to the central spindle and midbody during anaphase and telophase. [@matsumura2005]
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RACGAP1 — AlphaFold P47738 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RACGAP1 — Rac GTPase Activating Protein 1

gene · 2554 words

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Pathway Diagram

graph TD
    RACGAP1["RACGAP1"]
    neurodegeneration["neurodegeneration"]
    RACGAP1 -->|"implicated_in"| neurodegeneration
    style RACGAP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning RACGAP1 in their description or question text

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