protein

RAMP3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAMP3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The RAMP family consists of three related proteins (RAMP1, RAMP2, and RAMP3) that share a common structural architecture but confer distinct pharmacological properties when paired with CALCRL.

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🔬 Protein Info

Gene Symbol	RAMP3PROTEIN
Chromosome	7p13
Function	is a small single-pass transmembrane protein that plays a crucial role in determining the pharmacology and function of certain G protein-coupled receptors (GPCRs).
Primary Expression	the nervous and cardiovascular systems - Pharmacology: Sensitive to CGRP receptor antagonists (e
Molecular Weight	17 kDa
Amino Acids	175 aa
GeneCards	RAMP3PROTEIN
Human Protein Atlas	RAMP3PROTEIN
CALCRL	Direct binding
Receptor activity-modifying protein 1 (RAMP1)	Potential heterodimerization
Receptor activity-modifying protein 2 (RAMP2)	Potential heterodimerization
SDR (small conductance calcium-activated potassium channel)	Functional interaction
CGRP receptor component protein (RCP)	Co-assembly
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ramp3-protein

protein · 1816 words

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Pathway Diagram

graph TD
    RAMP3PROTEIN["RAMP3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    RAMP3PROTEIN -->|"implicated_in"| neurodegeneration
    style RAMP3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found