gene

RASA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RASA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RASA2 is a RAS GTPase-activating protein that negatively regulates RAS signaling, implicated in cancer and potential roles in neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	RASA2
Full Name	RAS GTPase-Activating Protein 2
Function	is a member of the p120GAP (GTPase-activating protein) family that functions as a negative regulator of RAS signaling.
Molecular Weight	95 kDa
Amino Acids	878 aa
Pathways	PI3K
Ensembl ID	ENSG00000155903
GeneCards	RASA2
Human Protein Atlas	RASA2
N-terminal SH2 domain	Binds to phosphotyrosine-containing motifs, targeting RASA2 to activated receptor tyrosine kinases
N-terminal SH3 domain	Proline-rich region binding, mediates protein-protein interactions
GAP domain	Catalytic domain providing GTPase-activating function
C-terminal region	Regulatory and targeting functions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RASA2 — RAS GTPase-Activating Protein 2

gene · 1711 words

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Genes

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Pathway Diagram

graph TD
    RASA2["RASA2"]
    neurodegeneration["neurodegeneration"]
    RASA2 -->|"implicated_in"| neurodegeneration
    style RASA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found