gene

RASA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RASA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RASA2 is a RAS GTPase-activating protein that negatively regulates RAS signaling, implicated in cancer and potential roles in neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	RASA2
Full Name	RAS GTPase-Activating Protein 2
Function	is a member of the p120GAP (GTPase-activating protein) family that functions as a negative regulator of RAS signaling.
Molecular Weight	95 kDa
Amino Acids	878 aa
Pathways	PI3K
Ensembl ID	ENSG00000155903
GeneCards	RASA2
Human Protein Atlas	RASA2
Scaffolding	RASA2 can function as a scaffold to bring together signaling components
Effector functions	Some GAPs have effector functions independent of their catalytic activity
Cellular localization	RASA2 is recruited to specific subcellular compartments to regulate local RAS signaling
LTP (Long-Term Potentiation)	RASA2 modulates RAS-ERK signaling required for LTP induction and maintenance
LTD (Long-Term Depression)	RASA2 regulation of RAS signaling affects LTD
Dendritic spine morphology	RAS signaling influences spine shape and number
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RASA2 — RAS GTPase-Activating Protein 2

gene · 1711 words

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Pathway Diagram

graph TD
    RASA2["RASA2"]
    neurodegeneration["neurodegeneration"]
    RASA2 -->|"implicated_in"| neurodegeneration
    style RASA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RASA2 in their description or question text

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