gene

RASGRF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RASGRF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RASGRF2 - Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2 - A calcium/calmodulin-regulated GEF for Ras and Rac GTPases in dopaminergic signaling

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🧬 Gene Info

Gene Symbol	RASGRF2
Full Name	Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2
Chromosome	5q14.1
Function	is a calcium/calmodulin-regulated guanine nucleotide exchange factor (GEF) that activates Ras and Rac GTPases.
Primary Expression	the striatum, hippocampus, and cortex, making it particularly relevant to neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer'
Subcellular Localization	CaMKII regulates RasGRF2 through direct phosphorylation
Amino Acids	1355 aa
UniProt ID	O14827
NCBI Gene ID	10237
Ensembl ID	ENSG00000101938
OMIM	608099
GeneCards	RASGRF2
Human Protein Atlas	RASGRF2
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RASGRF2 — AlphaFold O14827 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RASGRF2

gene · 2017 words

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RASGRF2 (Ras-GRF2) Protein

protein · 1302 words

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Pathway Diagram

graph TD
    RASGRF2["RASGRF2"]
    neurodegeneration["neurodegeneration"]
    RASGRF2 -->|"implicated_in"| neurodegeneration
    style RASGRF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RASGRF2 in their description or question text

No additional research found