gene

REG3G

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REG3G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

1Analyses

2Outgoing

0Incoming

0Experiments

1Debates

Summary

Regenerating Family Member 3 Gamma - a C-type lectin with gut-brain axis implications in neurodegeneration

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🧬 Gene Info

Gene Symbol	REG3G
Aliases	Regenerating Family Member 3 Gamma
Chromosome	19p13.3
Function	encodes a C-type lectin (also known as REG3G or PAP1-gamma) expressed primarily in the gastrointestinal tract.
Primary Expression	Small intestine, colon, pancreas, immune cells
Molecular Weight	16 kDa
Amino Acids	175 aa
Pathways	NF-κB signaling
UniProt ID	Q8WXA8
NCBI Gene ID	286101
Ensembl ID	ENSG00000144229
GeneCards	REG3G
Human Protein Atlas	REG3G
N-terminal signal peptide	Directs secretion
C-type lectin domain	Carbohydrate-binding activity
Associated Diseases	alpha-synuclein pathology
KG Connections	2 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: REG3G — AlphaFold Q8WXA8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

REG3G Gene

gene · 1775 words

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REG3G Protein

protein · 650 words

→

Pathway Diagram

graph TD
    REG3G["REG3G"]
    neurodegeneration["neurodegeneration"]
    REG3G -->|"implicated_in"| neurodegeneration
    style REG3G fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
alpha-synuclein pathology	decreases_risk	phenotype	0.70
alpha-synuclein pathology	regulates	disease	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.699

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract claims C. butyricum-GLP-1 crosses the BBB and binds to GLP-1 recept

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning REG3G in their description or question text

No additional research found