gene

REG3G

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REG3G: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Regenerating Family Member 3 Gamma - a C-type lectin with gut-brain axis implications in neurodegeneration

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🧬 Gene Info

Gene Symbol	REG3G
Aliases	Regenerating Family Member 3 Gamma
Chromosome	19p13.3
Function	encodes a C-type lectin (also known as REG3G or PAP1-gamma) expressed primarily in the gastrointestinal tract.
Primary Expression	Small intestine, colon, pancreas, immune cells
Molecular Weight	16 kDa
Amino Acids	175 aa
Pathways	NF-κB signaling
UniProt ID	Q8WXA8
NCBI Gene ID	286101
Ensembl ID	ENSG00000144229
GeneCards	REG3G
Human Protein Atlas	REG3G
Gene Name	Regenerating Family Member 3 Gamma
Protein Class	C-type lectin, antimicrobial protein
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: REG3G — AlphaFold Q8WXA8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    REG3G["REG3G"]
    neurodegeneration["neurodegeneration"]
    REG3G -->|"implicated_in"| neurodegeneration
    style REG3G fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity