Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RGS9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | RGS9 |
| Full Name | Regulator of G Protein Signaling 9 |
| Chromosome | 17q24.2 |
| Protein Type | Receptor |
| Function | encodes a member of the RGS family of GTPase-activating proteins with particularly high expression in the striatum and retina [1][2]. |
| Amino Acids | 120 aa |
| UniProt ID | Q9NS28 |
| NCBI Gene ID | 8788 |
| Ensembl ID | ENSG00000108370 |
| OMIM | 604521 |
| GeneCards | RGS9 |
| Human Protein Atlas | RGS9 |
| N-terminal Extension | RGS9 contains an extended N-terminal region that mediates protein-protein interactions |
| GAGE Domain | A unique GAGE domain found in several RGS proteins involved in intracellular targeting |
| Dephosphorylation Regulation | RGS9 activity is regulated by phosphorylation, with PP1-mediated dephosphorylation enhancing its GAP activity |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RGS9["RGS9"]
neurodegeneration["neurodegeneration"]
RGS9 -->|"implicated_in"| neurodegeneration
style RGS9 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RGS9 in their description or question text
No additional research found