RIPK3

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolRIPK3
Namereceptor interacting serine/threonine kinase 3
Typeprotein-coding
Sourcemygene

Summary

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-ka

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