Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ROR2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ROR2PROTEIN |
| Protein Type | Receptor |
| Function | is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family that functions as a receptor for Wnt ligands, primarily Wnt5a. |
| Primary Expression | adult tissues including the brain |
| Subcellular Localization | </span><span class="infobox-value">Plasma membrane, Primary cilia</span></div> |
| Molecular Weight | 110 kDa |
| Amino Acids | 943 aa |
| GeneCards | ROR2PROTEIN |
| Human Protein Atlas | ROR2PROTEIN |
| CRD (Cysteine-rich Domain) | The extracellular CRD directly binds Wnt5a and other Wnt ligands. Unlike Frizzled receptors, ROR2 CRD shows distinct binding specificity for non-canonical Wnts. |
| Kringle Domains | These domains mediate protein-protein interactions and may contribute to receptor oligomerization. |
| Inactive Kinase Domain | ROR2 possesses a kinase domain with mutations that impair catalytic activity. Instead, it functions as a scaffoldsome assembly platform, recruiting downstream signaling proteins. |
| Primary Cilia Localization | ROR2 localizes to primary cilia, where it participates in cilia-dependent signaling pathways. |
| Glycosylation | Heavily N-glycosylated in the extracellular domain |
| Phosphorylation | Several tyrosine and serine/threonine phosphorylation sites |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ROR2PROTEIN["ROR2PROTEIN"]
neurodegeneration["neurodegeneration"]
ROR2PROTEIN -->|"implicated_in"| neurodegeneration
style ROR2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ROR2PROTEIN in their description or question text
No additional research found