gene

RPL13

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about RPL13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: RPL13 - ribosomal protein L13 involved in protein synthesis and implicated in neurodegenerative disease pathogenesis through ribosomal dysfunction, translation dysregulation, and stress granule formation.

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🧬 Gene Info

Gene Symbol	RPL13
Full Name	Ribosomal Protein L13
Aliases	Gene profile: RPL13
Chromosome	16q24.3
Function	encodes an essential ribosomal protein that constitutes a core component of the large 60S ribosomal subunit.
Gene Type	Protein coding
UniProt ID	P26373
NCBI Gene ID	6142
GeneCards	RPL13
Human Protein Atlas	RPL13
Component	Large (60S) ribosomal subunit
eIF2α phosphorylation	Global translation inhibition
Stress granule accumulation	Sequestration of mRNAs and proteins
Mitochondrial translation defect	Energy production failure
Synaptic translation loss	Synapse dysfunction
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPL13 — AlphaFold P26373 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["RPL13"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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