gene

RPS12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: RPS12

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🧬 Gene Info

Gene Symbol	RPS12
Full Name	Ribosomal Protein S12
Chromosome	6p22.1
Function	RPS12 encodes Ribosomal Protein S12, a component of the small (40S) ribosomal subunit.
Pathways	mTOR
UniProt ID	P25311
NCBI Gene ID	6206
GeneCards	RPS12
Human Protein Atlas	RPS12
Pontocerebellar Hypoplasia (PCH)	Primary neurological manifestation associated with RPS12 mutations
Ribosomopathies	Disease category encompassing ribosomal dysfunction disorders
40S Ribosomal Subunit	Structural context for RPS12 function
Unfolded Protein Response (UPR)	Cellular stress pathway activated by RPS12 dysfunction
Other Ribosomal Proteins	RPS19, RPL5, and RPL11 (associated proteins in related neurodegenerative diseases)
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPS12 — AlphaFold P25311 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RPS12 — Ribosomal Protein S12

gene · 648 words

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RPS12 Protein — Ribosomal Protein S12

protein · 1146 words

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Pathway Diagram

graph TD
    RPS12["RPS12"]
    neurodegeneration["neurodegeneration"]
    RPS12 -->|"implicated_in"| neurodegeneration
    style RPS12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RPS12 in their description or question text

No additional research found