gene

RPS6KA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPS6KA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

RPS6KA2 (p90RSK3) is a serine/threonine kinase downstream of ERK1/2 signaling. It regulates cell proliferation, synaptic plasticity, and neuronal survival. Dysregulation is linked to Alzheimer's disease, Parkinson's disease, and cancer.

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🧬 Gene Info

Gene Symbol	RPS6KA2
Full Name	Ribosomal Protein S6 Kinase A2
Aliases	p90RSK3
Protein Type	Kinase
Function	is a member of the p90 ribosomal S6 kinase (RSK) family of serine/threonine protein kinases.
Primary Expression	neuronal tissues and has been increasingly studied for its roles in neurodevelopment and neurodegeneration
Amino Acids	733 aa
Pathways	MAPK
Ensembl ID	ENSG00000071242
GeneCards	RPS6KA2
Human Protein Atlas	RPS6KA2
ERK1/2 binding	Through D-domain motifs in the C-terminus
Phosphorylation by ERK1/2	At Ser380 (major activation site)
Autophosphorylation	Subsequent autophosphorylation at multiple sites
PDK1 phosphorylation	At Thr577 in the N-terminal kinase domain
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RPS6KA2 — Ribosomal Protein S6 Kinase A2

gene · 1344 words

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Pathway Diagram

graph TD
    RPS6KA2["RPS6KA2"]
    neurodegeneration["neurodegeneration"]
    RPS6KA2 -->|"implicated_in"| neurodegeneration
    style RPS6KA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning RPS6KA2 in their description or question text

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