Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPS7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene page for RPS7 (Ribosomal Protein S7), a component of the 40S ribosomal subunit involved in protein synthesis, p53 activation, and associated with Diamond-Blackfan anemia and cancer.
| Gene Symbol | RPS7 |
| Aliases | Ribosomal Protein S7 |
| Chromosome | 2p25.3 |
| Function | encodes a protein of 194 amino acids. |
| Primary Expression | neurons and glial cells, contributing to synaptic protein synthesis and neuronal homeostasis |
| Molecular Weight | 22.5 kDa |
| Amino Acids | 194 aa |
| Ensembl ID | ENSG00000171863 |
| GeneCards | RPS7 |
| Human Protein Atlas | RPS7 |
| Ribosomal Stress Response | When ribosome assembly is impaired, excess RPS7 binds MDM2 |
| p53-Dependent Apoptosis | This leads to p53 activation and removal of cells with ribosomal defects |
| Prevention of Transformation | The pathway prevents the accumulation of cells with genomic instability |
| Bone marrow | Active hematopoiesis requires high protein synthesis |
| Proliferating cells | Cell division requires increased translational capacity |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RPS7["RPS7"]
neurodegeneration["neurodegeneration"]
RPS7 -->|"implicated_in"| neurodegeneration
style RPS7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity