Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RPUSD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RPUSD4 encodes mitochondrial RNA pseudouridine synthase D4, critical for mitochondrial translation and linked to neurodegeneration.
No AI portrait yet
| Gene Symbol | RPUSD4 |
| Full Name | RNA Pseudouridine Synthase D4 |
| Chromosome | 9q34.3 |
| Protein Family | Pseudouridine synthase (Pus) |
| Protein Type | Synthase |
| Function | encodes a mitochondrial pseudouridine synthase that catalyzes the isomerization of uridine to pseudouridine (ψ) in mitochondrial rRNA and tRNA molecules[@wu2023]. |
| Primary Expression | tissues with high metabolic demand, including brain, heart, and skeletal muscle, where mitochondrial dysfunction has profound pathological consequence |
| Molecular Weight | 52 kDa |
| Amino Acids | 461 aa |
| UniProt ID | Q8N5K2 |
| NCBI Gene ID | 285456 |
| Ensembl ID | ENSG00000156575 |
| OMIM | 614739 |
| GeneCards | RPUSD4 |
| Human Protein Atlas | RPUSD4 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RPUSD4["RPUSD4"]
neurodegeneration["neurodegeneration"]
RPUSD4 -->|"implicated_in"| neurodegeneration
style RPUSD4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RPUSD4 in their description or question text
No additional research found