Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Repair: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Lysosome Quality Control | involved_in | pathway | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of EMT states in SCC | exploratory | Skin squamous cell carcinoma | 0.900 | 0.00 | Primary mouse model | proposed | N/A |
| Gene expression analysis of autophagy targets following trehalose trea | exploratory | motoneuron degeneration | 0.850 | 0.00 | neuronal cell lines | proposed | N/A |
| Trehalose-induced autophagy gene expression analysis | exploratory | motoneuron degeneration | 0.850 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
| Autophagy Enhancement Drug Screening for Neurodegeneration | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Presymptomatic GRN Carrier Intervention Timing — Biomarker-Guided Ther | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral de [PMID:40934925] | Sitron CS, Trinkaus VA, Galesic A, Garha | Mol Cell | 2025 | 1 |
| Compromised function of the ESCRT pathway promotes endolysosomal escape of tau s [PMID:31578281] | Chen JJ, Nathaniel DL, Raghavan P, Nelso | J Biol Chem | 2019 | 1 |
| Overexpression of the ERG oncogene in prostate cancer identifies candidates for [PMID:41632544] | Köcher S, Elsesy ME, Moustafa A, Mohamma | J Clin Invest | 2026 | 0 |
| Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604] | Casazza KM, Williams GM, Johengen L, Kel | bioRxiv | 2026 | 0 |
| Genetic variations in base excision repair genes and the risk of developing hepa [PMID:41844453] | Shao B, Yin H, Zhang S, He S, Lu H et al | Cancer Genet | 2026 | 0 |
| Parkinson's disease linked LRRK2 G2019S drives oxidative nuclear DNA damage and [PMID:41889852] | Liu J, Gonzalez-Hunt CP, Richbourg T, Ba | bioRxiv : the preprint server | 2026 | 0 |
| PARG inhibition sequesters nuclear PAR-binding proteins, including XRCC1 and its [PMID:41890038] | Dumoulin I, Lee BJ, Zhang C, Lin X, Wang | bioRxiv | 2026 | 0 |
| Function of HIF-1α in Regulation of Antioxidative Stress of Tribolium castaneum [PMID:41899005] | Wan Z, Li X, Wang Y, Miao S, Chen Z et a | Insects | 2026 | 0 |
| Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XR [PMID:41922367] | Dauben H, Mihaljević M, Kolvenbach A, Pa | Nat Commun | 2026 | 0 |
| Mislocalization of FTD3-associated mutant CHMP2B to the nucleus of human neurons [PMID:41559796] | ["Jun Y", "Hass E", "Lee S", "Fazzio T", | Acta neuropathologica communic | 2026 | 0 |
| Spatially resolved translational dysregulation in [PMID:41509319] | ["Wu M", "Huang J", "Aryal S", "Farsi Z" | bioRxiv : the preprint server | 2025 | 0 |
| Increased granulovacuolar degeneration in the thalamus and higher neurofibrillar [PMID:40889877] | ["Nagakura A", "Kawakami I", "Kimura A", | Psychiatry and clinical neuros | 2025 | 0 |
| Canagliflozin attenuates neurodegeneration and ameliorates dyskinesia through ta [PMID:39700958] | ["Abdelaziz A", "Rasheed N", "Zaki H", " | International immunopharmacolo | 2025 | 0 |
| Loss of CHMP2A implicates an ordered assembly of ESCRT-III proteins during cytok [PMID:40928930] | Kamenetsky N, Nachmias D, Khan S, Avinoa | Molecular biology of the cell | 2025 | 0 |
| The multi-dimensional regulatory mechanism of Sirt6 in heart health: From cell d [PMID:40902544] | Zhan S, Guo C, Yan H, Zheng G, Yan D | Biochemical and biophysical re | 2025 | 0 |
| Targeted autophagic clearance of Tau protects against Alzheimer's disease throug [PMID:40963907] | Yoon BH, Kim J, Sengupta S, Park CJ, Ko | Theranostics | 2025 | 0 |
| Pathological α-synuclein elicits granulovacuolar degeneration independent of tau [PMID:40537859] | ["Dues D", "Erb M", "Kasen A", "Vatsa N" | Translational neurodegeneratio | 2025 | 0 |
| Classical swine fever virus recruits ALIX and ESCRT-III to facilitate viral budd [PMID:39998268] | ["Chen J", "Yang H", "Wan M", "Cheng Y", | mBio | 2025 | 0 |
| The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and famil [PMID:41422089] | ["Jun Y", "Lee S", "Almeida S", "Freude | Nature communications | 2025 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Repair in their description or question text
Score: 0.630 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The pathophysiology of neuromyelitis optica spectrum disorder (NMOSD) centers on
Score: 0.550 · neurodegeneration · 2026-04-13
## Mechanistic Overview Oligodendrocyte DNA Repair Enhancement starts from the claim that modulating PARP1 within the di
Score: 0.538 · neurodegeneration · 2026-04-02
## Mechanistic Overview Lysosomal Membrane Repair Enhancement starts from the claim that modulating CHMP2B within the di
Score: 0.530 · neurodegeneration · 2026-04-21
## Mechanistic Overview PI3P Generation at Damaged Lysosomes Promotes Membrane Repair starts from the claim that modulat
Score: 0.430 · neurodegeneration · 2026-04-21
## Mechanistic Overview DNA Damage Repair Dysfunction Creating TDP-43 Pathology Feed-Forward Loop starts from the claim
Score: 0.385 · connectomics · 2026-04-26
This hypothesis proposes that microglial TREM2 activation serves as a master regulator that coordinates both synaptic pr
Score: 0.000 · unknown disease · 2026-04-28
Creating controlled gradients of astrocyte subtypes across damaged brain regions could optimize both neuroprotection and