Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Retromer dysfunction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| impaired autophagic flux in neurons | causes | mechanism | 0.70 |
| APP mislocalization | causes | mechanism | 0.70 |
| Aβ production | causes | phenotype | 0.70 |
| Tau Fibrillization | causes | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottl | 0.700 | neurodegeneration | - |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 0 hypotheses
proteomics | 2026-04-16 | 19 hypotheses Top: 0.591
neurodegeneration | 2026-04-07 | 6 hypotheses Top: 0.740
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.66 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
Hypotheses and analyses mentioning Retromer dysfunction in their description or question text
No additional research found