gene

SARS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SARS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

Seryl-tRNA Synthetase 1 - enzyme essential for protein synthesis, mutations cause Charcot-Marie-Tooth disease and neurodevelopmental disorders

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🧬 Gene Info

Gene Symbol	SARS1
Aliases	Seryl-tRNA Synthetase 1
Protein Type	Synthetase
Function	The enzyme catalyzes the following reaction
Amino Acids	514 aa
Ensembl ID	ENSG00000022771
GeneCards	SARS1
Human Protein Atlas	SARS1
Motor symptoms	Weakness and atrophy of distal muscles
Sensory deficits	Reduced sensation in feet and hands
Onset	Variable, typically adolescence to adulthood
Progression	Gradual deterioration over decades
Intellectual disability	Varying degrees
Developmental delay	Global developmental delays
Microcephaly	Reduced head circumference in some patients
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SARS1

gene · 833 words

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Genes

index · 271 words

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Pathway Diagram

graph TD
    SARS1["SARS1"]
    neurodegeneration["neurodegeneration"]
    SARS1 -->|"implicated_in"| neurodegeneration
    style SARS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (1)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity