Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SASP modulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| BDNF preservation | protective_against | mechanism | 0.70 |
| cognitive preservation | protective_against | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SASP Modulation Rather Than Cell Elimination | 0.660 | - | Senescent cell clearance as neurodegener |
| NFκB/C1Q SASP Modulation for Synaptic Protection | 0.534 | neurodegeneration | What are the optimal oxygen pressure, du |
| Temporal SASP Modulation Rather Than Complete Senolytic Clea | 0.000 | - | Senescent cell clearance as neurodegener |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.769
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The physiopathology of brain-derived neurotrophic factor. [PMID:40490314] | Barde YA | Physiological reviews | 2025 | 0 |
| BDNF-enriched small extracellular vesicles protect against noise-induced hearing [PMID:37939851] | ["Min X", "Deng X", "Lao H", "Wu Z", "Ch | Journal of controlled release | 2023 | 0 |
| Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models [PMID:36787221] | Ge X, Zheng M, Hu M, Fang X, Geng D, Liu | The Journal of clinical invest | 2023 | 0 |
| Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in D [PMID:33096634] | ["Colucci-D'Amato L", "Speranza L", "Vol | International journal of molec | 2020 | 0 |
| Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in D [PMID:33096634] | Colucci-D'Amato L, Speranza L, Volpicell | Int J Mol Sci | 2020 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.44 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.81 · 2026-04-23
closed · Rounds: 4 · Score: 0.75 · 2026-04-16
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning SASP modulation in their description or question text
No additional research found