gene

SDHD

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SDHD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	SDHD
Chromosome	11q23.1
Protein Type	Gene
Function	Succinate dehydrogenase complex subunit D (SDHD) is a membrane-anchoring subunit of mitochondrial complex II (succinate dehydrogenase).
Amino Acids	159 aa
UniProt ID	O14521
GeneCards	SDHD
Human Protein Atlas	SDHD
SDHA	Flavoprotein subunit of Complex II
SDHB	Iron-sulfur subunit associated with tumor suppression
SDHC	Cytochrome b subunit of Complex II
Mitochondrial Electron Transport Chain	Oxidative phosphorylation system
Complex II Deficiency	Genetic disorder of mitochondrial metabolism
Succinate Metabolism	Metabolic pathway linked to inflammation
Paraganglioma	Primary tumor phenotype in SDHD mutation carriers
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SDHD — AlphaFold O14521 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

sdhd

gene · 642 words

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Pathway Diagram

graph TD
    SDHD["SDHD"]
    neurodegeneration["neurodegeneration"]
    SDHD -->|"implicated_in"| neurodegeneration
    style SDHD fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SDHD in their description or question text

No additional research found